State Route 110 (SR 110) is a 10.73-mile (17.27 km) state route that runs between Napoleon and north of McClure in the US state of Ohio. Most of the route is a rural two-lane highway and passes through both farmland and commercial properties. For much of its path, SR 110 runs generally parallel to the south of the Maumee River. The highway was first signed in 1923 on much the same alignment as today, bur got as far northeast as Perrysburg.