State Route 131 (SR 131) is a 30.05-mile (48.36 km) long east–west state highway in the southwestern quadrant of the U.S. state of Ohio. The western terminus of SR 131 is at a signalized intersection with U.S. Route 50 (US 50) in the eastern Cincinnati suburb of Milford. Its eastern terminus is at a T-intersection with SR 138 approximately 7.50 miles (12.07 km) southwest of Hillsboro.