State Route 141 (SR 141) is an east–west highway crossing through southeast Ohio, though it predominantly runs more north–south. Its western terminus is at U.S. Route 52 in Ironton. The eastern terminus at State Route 7 is in Gallipolis. The route is very scenic as it travels through rural areas of Lawrence and Gallia Counties. The road is hilliest in the westernmost 12 miles (19 km). As you move further east, the road becomes somewhat flatter as it often parallels Symmes Creek.