State Route 143 (SR 143, OH 143) is a north–south state highway in the southern portion of the U.S. state of Ohio. The southern terminus of State Route 143 is at a T-intersection with the concurrency of State Route 7 and State Route 124 approximately 1 mile (1.6 km) west of the village of Pomeroy. Its northern terminus is at a T-intersection with U.S. Route 50 nearly 2.75 miles (4.43 km) southwest of Albany.