State Route 145 (SR 145, OH 145) is a 46.14-mile (74.26 km) long north–south state highway in the southeastern quadrant of the U.S. state of Ohio. The western terminus of SR 145 is at a T-intersection with SR 821 in Lower Salem. Its eastern terminus is at a T-intersection with SR 148 approximately 5.25 miles (8.45 km) northeast of Beallsville.