State Route 161 (SR 161) is an east–west state highway in central Ohio. Its western terminus is in Mutual at State Route 29 and its eastern terminus is near Alexandria at State Route 37. It is 57.46 miles (92.47 km) long. State Route 161 passes through Columbus, Ohio's capital, and a variety of towns including Plain City, Dublin, and New Albany.The route was established in 1924 to connect Plain City and Dublin. It was later expanded to cover Mutual and Granville.