State Route 253 (SR 253, OH 253) is a very short east–west state highway in the southern part of the U.S. state of Ohio. With an overall length of just 0.56 miles (0.90 km), the majority of SR 253 is a part of the Jesse Stuart Memorial Bridge, which crosses over the Ohio River near Franklin Furnace, Ohio. The western terminus of SR 253 is at about the midspan of the bridge, where it crosses the Kentucky State Line and becomes Kentucky Route 10 (KY 10).