State Route 265 (SR 265) is an 18.33-mile-long (29.50 km) east–west state highway in the eastern portion of the U.S. state of Ohio. The western terminus of SR 265 is at its junction with US 40 approximately 2.50 miles (4.02 km) east of the city limits of Cambridge. The highway's eastern terminus is at a T-intersection with SR 147 nearly 3 miles (4.8 km) southwest of Barnesville.