State Route 288 (SR 288) is a 6.82-mile (10.98 km) long east–west state highway in the northern portion of the U.S. state of Ohio. The western terminus of SR 288 is at a T-intersection with SR 309 about 3 miles (4.8 km) southwest of Galion. Its eastern terminus is also at a T-intersection, this time with SR 97 approximately 5.50 miles (8.85 km) northwest of Lexington.