State Route 385 (SR 385) is an east–west state highway in the western portion of Ohio. The western terminus of State Route 385 is at U.S. Route 33 in New Hampshire, at a signalized intersection that doubles as the southern terminus of State Route 196. State Route 385's eastern terminus is at State Route 117 in the unincorporated community of Roundhead, less than two blocks northwest of State Route 117's junction with State Route 235.