State Route 39 (SR 39) is a primarily east–west running state highway in north-central and northeastern portion of the U.S. state of Ohio. The route runs through seven counties on its approximately 155-mile (249 km) trip through the region. Its northern terminus is at State Route 103 near New Washington, and its eastern terminus is at PA 68 near East Liverpool. Route 39 is unique in that its directional signage changes in the middle of its route.