State Route 501 (SR 501) is a north–south state highway in Auglaize and Allen Counties, Ohio. The southern terminus of State Route 501 is at an interchange with U.S. Route 33 (US 33) just south of Wapakoneta, which is also the western terminus for State Route 67 and the southern terminus for State Route 198. The route runs concurrently with both of the other two routes into Wapakoneta, and with State Route 198 only north of the village.