State Route 522 (SR 522) is an east–west state highway in the southern portion of the U.S. state of Ohio. State Route 522 has its western terminus is at a diamond interchange with U.S. Route 52 less than 3 miles (4.8 km) south of Wheelersburg. Its eastern terminus is at a T-intersection with State Route 93 just over 9 miles (14 km) north of Ironton.