Onondaga Reservation is an Indian reservation in Onondaga County, New York, United States. It is the territory of the Onondaga Nation. It lies just south of the city of Syracuse. The population was 468 at the 2010 census.The Onondaga Reservation is a politically independent entity, as the nation is federally recognized by the United States government. The Onondaga Nation has reached some accommodations with New York State on jurisdictional issues.