Packers Run is a tributary of the Susquehanna River in Northumberland County, Pennsylvania, in the United States. It is approximately 2.2 miles (3.5 km) long and flows through Point Township. The watershed of the stream has an area of 1.58 square miles (4.1 km2). The stream is designated as a Coldwater Fishery and a Migratory Fishery. There is at least one bridge in its watershed.