Pangani is a town in northeast Tanzania that lies 45 km south of Tanga, at the mouth of the Pangani River. It is the headquarters of Pangani District.Although archaeologists have found the remains of small 15th century settlements on the bluffs just north of Pangani, the modern town came to prominence in the nineteenth century, when, under nominal Zanzibari rule, it was a major terminus of caravan routes to the deep interior.