The Piggott Post Office is located at 119 North 3rd Street in central Piggott, Arkansas. It is a single-story brick building, with a flat roof that has an encircling parapet, and a concrete foundation. Construction on the building took place mostly in 1937, but was not completed until 1941. The building is noted for its lobby murals, painted by Iowa native Dan Rhodes, with funding from the United States Treasury Department's Section of Fine Arts, a Depression-era jobs program for artists.