Ponce de Leon is a town in Holmes County, Florida, United States. The population was 457 at the 2000 census. As of 2004, the population recorded by the U.S. Census Bureau is 462 [1].According to Ponce de Leon town Census 2010 results, the population of the area was approximately 598 people. From 2000 to 2010, the Ponce de Leon town population growth percentage was 30.9% (or from 457 people to 598 people).