Pythio (Greek: Πύθιο), sometimes referred to as Pythion, is a village and community in the eastern part of Didymoteicho municipality, Evros regional unit, Greece. It is 16 km east of the centre of Didymoteicho, on the right bank of the river Evros, where it forms the border with Turkey. There is no road border crossing near Pythio. The community of Pythio consists of the villages of Pythio, Rigio and Pythio railway station (Greek: Σταθμός Πυθίου Stathmos Pythiou).