The Séoune (French: la Séoune) is a 65-kilometre (40 mi) long river in the Lot, Tarn-et-Garonne and Lot-et-Garonne départements, southwestern France. Its source is at Sauzet. It flows generally southwest. It is a right tributary of the Garonne into which it flows between Lafox and Boé, near Agen.