Samuel Luther "Big Sam" Thompson (March 5, 1860 – November 7, 1922) was an American professional baseball player from 1884 to 1898 and with a brief comeback in 1906. At 6 feet, 2 inches, the Indiana native was one of the larger players of his day and was known for his prominent handlebar mustache. He played as a right fielder in Major League Baseball for the Detroit Wolverines (1885–88), Philadelphia Phillies (1889-1898) and Detroit Tigers (1906).