Highway 45 is a highway in the Canadian province of Saskatchewan. It runs from Highway 42/Highway 646 near Lucky Lake to Highway 7 near Delisle. Highway 45 is about 116 km (72 mi.) long.Highway 45 passes near Lucky Lake, Tullis, Birsay, Lyons, Macrorie, Swanson, Donavon, and Delisle. It connects with Highways 7, 654, 15, 646, 373, and 42.