Saskatchewan Highway 641 is a highway in the province of Saskatchewan, Canada, beginning at Highway 39 near Rouleau, and traveling north ending at Highway 15 at Semans. The highway intersects the Trans Canada Highway, Saskatchewan Highway 1 south of Pense and east of Belle Plaine, Highway 20 at Lumsden, and Highway 22 at Earl Grey. Local Improvement Districts were the precursors of rural municipalities which initially established and maintained roads in their area.