Scottsbluff is a city in Scotts Bluff County, in the western part of the state of Nebraska, in the Great Plains region of the United States. The population was 15,039 at the 2010 census. Scottsbluff is the largest city in the Nebraska Panhandle, and the 13th largest city in Nebraska.Scottsbluff was founded in 1899 across the North Platte River from its namesake, a bluff that is now a U.S. National Park called Scotts Bluff National Monument.