Sechler Run (also known as Sechler's Run) is a tributary of Mahoning Creek in Montour County, Pennsylvania, in the United States. It is 4.63 miles (7.45 km) long. The stream flows through Cooper Township, Mahoning Township, and Danville. Its only named tributary is Blizzards Run.A. Joseph Armstrong described Sechler Run in Danville as "on the whole uninviting" in his book Trout Unlimited's Guide to Pennsylvania Limestone Streams.