Sheldon Thompson (1785–1851) was mayor of Buffalo, New York, serving in 1840–1841. He was born in Derby, Connecticut on July 2, 1785. In early 1810, he moved to Lewiston, New York where he entered into the shipbuilding business and mercantile trade along the Great Lakes with Senior Partner, Jacob Townsend and Alvin Bronson.. He also entered the salt trade from the Onondaga salt mines. In April 1811, he married Catharine Barton. His daughter Sally Ann married Henry K.