Spithridates (in Greek Σπιθριδάτης; lived 4th century BC) was a satrap of Lydia and Ionia under the high king Darius III Codomannus and was one of the Persian commanders at the Battle of the Granicus, in 334 BC, in which engagement, while he was aiming a blow from behind at Alexander the Great, his arm was cut off by Cleitus, son of Dropides.