Srem District (Serbian: Сремски округ, Sremski okrug, pronounced [srɛ̂ːm], lit. "Syrmia District") is a northwestern district of Serbia. It lies in the regions of Syrmia and Mačva, in the autonomous province of Vojvodina. It has a population of 311,053. Seat of the district is in the city of Sremska Mitrovica.