State Route 157 (abbreviated SR 157) is a short secondary highway in northern Obion County, Tennessee. SR 157 begins at its junction with Tennessee State Route 22 and continues in a northerly direction toward the Kentucky/Tennessee state line, it passes through or nearby the unincorporated communities Walnut Log and Fishgap Hill, Tennessee. At the state line, the route changes to Kentucky Route 311 and continues on to Hickman, Kentucky.