State Route 181 (abbreviated SR 181) is a primary state highway running through Lake, Dyer, and Lauderdale counties in Tennessee. This highway traverses very sparsely populated areas and is located entirely within the flood plains of the Mississippi River, Obion River and Forked Deer River. SR 181 is constructed as a modern two-lane facility with paved shoulders and a 55 mph (89 km/h) speed limit throughout its length.