State Route 63 (SR 63) is an east–west state highway in the northern portion of eastern Tennessee. It goes from U.S. Route 27 (US 27) in Huntsville to SR 33 in Sneedville, running 102 miles (164 km).SR 63 is a primary route west of US 25E in Harrogate; the portion east of the I-75 junction in Caryville is part of Corridor F of the Appalachian Development Highway System, which stretches from Caryville to Jenkins, Kentucky.