Tobique First Nation is one of six Wolastoqiyik or Maliseet Nation reserves in New Brunswick, Canada.The Tobique Reserve is located on the north side of the Tobique River. The reserve comprises two lots (The Brother's # 18, 4 ha; Tobique # 20, 2724 ha). The Tobique Reserve, established in 1801 with nearly 20,000 acres, was granted after a petition to the government by band members. Over the years, the reserve was reduced by surrenders to squatters and a major surrender in 1892.