Trikala (Greek: Τρίκαλα) is a city in northwestern Thessaly, Greece, and the capital of the Trikala regional unit. The city straddles the Lithaios river, which is a tributary of Pineios. According to the National Statistical Service, Trikala is populated by 81,355 inhabitants (2011), while in total the Trikala regional unit is populated by 131,085 inhabitants (2011).