U.S. Route 123 (US 123) is a spur of US 23 in the U.S. states of Georgia and South Carolina. The U.S. Highway runs 75.12 miles (120.89 km) from US 23, US 441, and SR 365 near Clarkesville, Georgia, north and east to Interstate 385 Business (I-385 Business) in Greenville, South Carolina.