U.S. Route 25E is the eastern branch of U.S. Route 25 from Newport, Tennessee, where US 25 splits into US 25E and US 25W, to North Corbin, Kentucky, where the two highways rejoin. The road, however, continues as US 25E for roughly 2 miles (3.2 km) until it joins Interstate 75 in North Corbin.All of US-25E in Tennessee is now the East Tennessee Crossings Byway, a National Scenic Byway. A portion of US 25E in Tennessee is also designated as Appalachian Development Corridor S.