U.S. Highway 57 is a north–south United States highway that follows a nearly east–west route in southwest Texas. The highway's northern (eastern) terminus is about 50 miles (80 km) south of San Antonio, Texas, between Devine and Pearsall, at an intersection with Interstate 35 (old U.S. Highway 81). Its southern (western) terminus is in Eagle Pass, at the Rio Grande (Río Bravo), where it continues into Piedras Negras, Coahuila, as Mexican Federal Highway 57.