U.S. Route 67 is a 1,560 mile (2,511 km) long north–south U.S. highway in the Central United States. The southern terminus of the route is at the United States-Mexico border in Presidio, Texas, where it continues south as Mexican Federal Highway 16 upon crossing the Rio Grande. The northern terminus is at U.S. Route 52 in Sabula, Iowa.US 67 crosses the Mississippi River twice along its routing.