"Uncertainty Principle" is the second episode of the first season of the American television series Numb3rs. Based on a real bank robbery case, the episode features a Federal Bureau of Investigation (FBI) math consultant's prediction being incomplete after FBI agents find themselves in an unexpected shootout with suspected bank robbers. Series writers Cheryl Heuton and Nicolas Falacci wanted to explore the emotional effects of the case on Dr. Charlie Eppes (David Krumholtz).