State Route 22 (SR 22) is a primary state highway in the U.S. state of Virginia. The state highway runs 29.81 miles (47.97 km) from U.S. Route 250 in Shadwell east to US 522 and SR 208 in Mineral. SR 22 is one of two primary east–west highways in Louisa County, connecting the county seat of Louisa with Charlottesville and Mineral. The state highway runs concurrently with US 33 through Louisa and with SR 208 between Louisa and Mineral.