Virginia State Route 253 (SR 253) is a primary state highway in the U.S. state of Virginia. Known as Port Republic Road, the state highway runs 12.18 miles (19.60 km) from U.S. Route 11 (US 11) in Harrisonburg east to US 340 near Port Republic. SR 253 is a northwest–southeast highway that connects Harrisonburg with Cross Keys and Port Republic in southeastern Rockingham County. The state highway also provides access to portions of James Madison University on either side of Interstate 81 (I-81).