State Route 43 (SR 43) is a primary state highway in the U.S. state of Virginia. The state highway consists of two disjoint segments that have a total length of 61.20 miles (98.49 km). The southern portion of the state highway runs 39.79 miles (64.04 km) from U.S. Route 29 Business (US 29 Bus.) in Altavista north to the Blue Ridge Parkway at Peaks of Otter. The northern segment has a length of 21.41 miles (34.46 km) between the Blue Ridge Parkway near Buchanan and US 220 in Eagle Rock.