Virginia State Route 45 (SR 45) is a primary state highway in the U.S. state of Virginia. The state highway runs 39.72 miles (63.92 km) from the junction of U.S. Route 15 Business and US 460 Business in Farmville north to SR 6 at Georges Tavern. SR 45 is the primary north–south highway of Cumberland County, where the highway meets US 60 near the county seat, Cumberland.