State Route 6 (SR 6) is a primary state highway in the U.S. state of Virginia. Known for most of its length as River Road, the state highway runs 102.26 miles (164.57 km) from U.S. Route 250 (US 250) in Afton east to SR 161 in Richmond. SR 6 is one of the main highways of mountainous Nelson County, where the highway runs north–south from its beginning to US 29. From Scottsville to Richmond, the state highway parallels the James River.