State Route 78 (SR 78) is a primary state highway in the U.S. state of Virginia. The state highway runs 3.85 miles (6.20 km) from U.S. Route 23 Business (US 23 Business) north to SR 600 at Stonega. SR 78 connects Appalachian with several coal mining communities in western Wise County. The state highway became a primary state highway, SR 62, in the early 1940s. SR 78 received its present number in the mid-1940s when current SR 62 received its designation.