Walpole Island is an island and First Nation reserve in southwestern Ontario, Canada, on the border between Ontario and Michigan in the United States. It is located in the mouth of the St. Clair River on Lake St. Clair, about 121 kilometres (75 mi) by road from Windsor, Ontario and 124 kilometres (77 mi) from Detroit, Michigan.In addition to Walpole Island, the reserve includes Squirrel, St. Anne, Seaway, Bassett, and Potawatomi islands.