State Route 220 (SR 220) was a 27.42-mile (44.13 km) long state highway located entirely in the Yakama Indian Reservation, Yakima County, Washington, United States. The highway linked Fort Simcoe State Park in the west to White Swan and Toppenish in the east. The highway had been built sometime between 1915 and 1937, and was renumbered from Secondary State Highway 3B during the 1964 state highway renumbering.