Wayne is a town in McClain County, Oklahoma, United States. Wayne and McClain County are part of the Oklahoma City Metropolitan Area The population was 519 according to the 2000 census and is part of the "Heart of Oklahoma" area. Wayne was so named by early railroad workers from Pennsylvania who adopted town names from the railways there, including Wayne, Paoli, Ardmore, and Wynnewood. Wayne is named for Mad Anthony Wayne a United States Army general and statesman. Gen.