West Virginia Route 88 is a north–south state highway located within the Northern Panhandle of West Virginia. The southern terminus is at U.S. Route 250 in Limestone. The northern terminus is at West Virginia Route 27 five miles (8 km) east of Wellsburg and 400 yards (370 m) west of the Pennsylvania border.WV 88 is cosigned with U.S. Route 40 (National Road) from Elm Grove to Woodsdale. It originally terminated in Marshall County, West Virginia.