Zuni is an unincorporated community in Isle of Wight County in the Hampton Roads region of southeastern Virginia in the United States.Zuni is home to a dentist's office, a Ruritan club, a general store, a gas station, and two churches and is served by its own Post Office. The name is properly pronounced ZOO-nigh. Articles written about Zuni on the internet say that Zuni was also home to hotels, a bank and other businesses in the mid-20th century.