. . "Big Isaac, West Virginia"@en . . "-5" . . "304 & 681" . "-4" . . . "Big Isaac is an unincorporated community in Doddridge County, West Virginia, United States. Big Isaac is 6 miles (9.7 km) south-southeast of Salem, along Laurel Run, a headwaters tributary of Meathouse Fork. The Big Isaac Post Office closed on December 31, 1962.Big Isaac WV postmark, last day"@en . . "299.923"^^ .